Arsenal will launch their Premier League title defence at home to newly promoted Coventry City after the 2026-27 fixture list was unveiled on Friday.
The champions, who ended a 22-year wait for the title last season, welcome Frank Lampard's Coventry to the Emirates Stadium on 21 August in one of the standout fixtures of the opening weekend.
Coventry return to the Premier League for the first time in 25 years after securing promotion by winning the Championship, setting up a dream opening clash against Mikel Arteta's side.
Liverpool's new chapter under Andoni Iraola will begin away at Newcastle United on 23 August. The former Bournemouth manager will then take charge of his first Premier League match at Anfield the following weekend against Nottingham Forest.
Manchester City will start life after Pep Guardiola with a home fixture against Bournemouth on 23 August. Guardiola stepped down at the end of last season after a trophy-laden decade at the Etihad Stadium, with former Chelsea boss Enzo Maresca widely expected to take over.
Meanwhile, Chelsea's new manager Xabi Alonso faces an immediate test as he begins his reign with a west London derby away to Fulham on 24 August.
Hull City, back in the Premier League for the first time since 2017 after winning the Championship play-offs, host Manchester United on 22 August.
Fellow promoted side Ipswich Town begin their campaign at home to Sunderland on the same day.
Elsewhere during the opening weekend, Europa League winners Aston Villa travel to Brighton, Brentford host Tottenham Hotspur, Everton welcome Crystal Palace, and Leeds United visit Nottingham Forest.
After facing Coventry, Arsenal's title defence quickly intensifies.
Arteta's side travel to Aston Villa for their first away match before hosting Chelsea on 5 September. Further trips to Sunderland and Brighton follow during a challenging opening stretch.
One of the most anticipated fixtures of the season arrives on 12 September when Manchester City and Manchester United meet in the first Manchester derby of the post-Guardiola era.
Liverpool host Manchester United on 21 November, while Arsenal's first league meeting with City is scheduled for 28 November at the Emirates Stadium.
The first Merseyside derby of the campaign takes place on 28 November, with Everton hosting Liverpool at the Hill Dickinson Stadium.
Tottenham manager Roberto De Zerbi will experience his first north London derby on 5 December when Spurs welcome Arsenal.
Another notable festive fixture sees Coventry boss Frank Lampard face former club Chelsea on Boxing Day, 26 December.
Liverpool travel to Old Trafford on 23 January before Arsenal visit Manchester City at the Etihad Stadium a week later.
The 2026-27 Premier League season concludes on 30 May.
Arsenal finish at home against Brighton, Manchester City travel to Sunderland, and Liverpool host Bournemouth. Chelsea's final match is at home to Brentford, while Manchester United welcome Fulham to Old Trafford.
The season's start and finish dates have been pushed back due to the World Cup, which concludes just 34 days before the Premier League campaign begins.
Before league action gets underway, Arsenal will face FA Cup winners Manchester City in the Community Shield on 16 August, the traditional curtain-raiser to the English football season.